Petasites japonicus Ethanol Extract Inhibited Collagen-Induced Platelet Aggregation and Thrombus Formation in Rats
نویسنده
چکیده
Petasites japonicus (P. japonicus), a perennial plant of Asteraceae family, has been reported for antioxidant, anti-obesity and anti-allergic effects. However, the anti-platelet and anti-thrombotic activities of this plant were remained unclear. Therefore, this study aimed to portray the anti-platelet and anti-thrombotic properties of P. japonicus ethanol extract (PJET) in rats. PJET (31 -500 μg/ml) impaired in vitro collagen-stimulated platelet aggregation, [Ca2+]i mobilization and ATP secretion dose dependently. Moreover, PJET attenuated p38 mitogen-activated protein kinase, c-Jun N-terminal kinase 1 (JNK1) and extracellular-signalregulated protein kinase 2 (ERK2) protein phosphorylations. Likewise, PJET diminished thrombus formation in extracorporeal shunt model. In conclusion, PJET could be a source of potential natural compounds that reduce disseminated intravascular platelet aggregation and thrombus formation.
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